Diagnostic significance of CT quantitative detection in chronic lung disease

Abstract

Objective To explore the diagnostic value of CT quantitative detection in chronic obstructive pulmonary disease (COPD). Methods A total of 113 patients with suspected COPD who were hospitalized in an outpatient department of a hospital from January 2018 to December 2020 were selected as the subjects of study. All patients underwent CT quantitative examination, lung function and other related examinations. The results of lung function examination were used as the gold standard to detect COPD, and the application of CT quantitative examination in the diagnosis of COPD was analyzed. Results Among 157 suspected patients with C0PD, 112 (71.34%) were COPD and 20 (12.74%) were bronchial asthma; The forced expiratory volume (FEV,), forced vital capacity (FVC) and FEV,/FVC value, mean lung density (MLD) and lumen area (LA) in the first second of COPD group were lower than those in the non-COPD group. The respiratory biphasic voxel index<- 950HU lung volume accounted for the percentage of total lung volume [VI-950 (%)] and the percentage of wall area (WA%) in the COPD group were higher than those in the non-COPD group, and the difference was statistically significant (P<0.05); The results of bivariate Spearson correlation test showed that FEV,/FVC were negatively correlated with VI-950 and WA% (r<0, P<0.05), and positively correlated with MLD and LA (r>0, P<0.05); The ROC curve results show that the AUC of quantitative detection of VI-950, MLD, LA, WA% for COPD by rCT is more than 0.7, which has high predictive value. When the best threshold is obtained, the best predictive value can be obtained. Conclusion CT quantitative detection has high diagnostic efficiency in the differential diagnosis of COPD, and can provide objective reference for clinical early examination.