Application of Microbial Intestinal Brain Axis Theory in the Nursing of Autism Spectrum Disorder

Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder centered around social disorders and stereotyped behavior, with its global prevalence increasing year by year.

Traditional behavior and medication interventions have limited effectiveness. In recent years, the progress of the microbiota gut brain (MGB) axis theory has provided new directions for the etiology research and clinical nursing of ASD. The imbalance of gut microbiota in children with ASD can exacerbate neuroinflammation through neuroimmune mechanisms, further affecting central nervous system development. The nursing intervention strategy based on MGB axis can improve gastrointestinal symptoms and behavioral abnormalities in children with ASD. However, microbial intervention still faces multiple challenges. This review systematically integrates the clinical application and mechanism exploration of MGB axis in ASD, and constructs a nursing practice framework based on the existing research results of MGB axis, providing multidimensional theoretical support and practical path for optimizing ASD clinical nursing strategies.