The Impact of Four Types of Cholesterol Binding on Cognitive Function

Abstract

 Background: Cognitive impairment has been linked to dyslipidemia. Nevertheless, the precise mechanisms through which triglycerides (TG), LDL-C, HDL-C, and TC influence cognitive function remain unclear. Objectives: This study investigates the relationship between blood lipid levels and cognitive function in a cohort of adults. Methods: Five thousand patients (65.4 ±12.3 years of age) were studied in a longitudinal study. Cognitive outcomes in the intensive care unit (ICU) were associated with baseline Glasgow Coma Scale (GCS) scores and serum lipid levels. Linear regression models were applied to study the relationship of cholesterol and GCS scores. Results: The Findings indicated there was a direct positive relationship of TC and LDL-C while a direct positive relationship of HDL-C with positive cognitive outcome scores, which form of GCS scores. Instead, sources of high TGs corresponded to worse cognitive abilities. Conclusion: These findings showed that lipid profiles, particularly TC, LDL-C and HDL-C profiles, are important predictors of cognitive functioning among intensive care unit patients. This speaks volumes to control the level of cholesterol to remain at the same level.