Guanosine-Based Hydrogel Intelligent Delivery Systems

Abstract

The guanosine-based hydrogel intelligent delivery system represents a novel transport platform capable of precise control over release behavior. This system utilizes guanosine-containing hydrogels with stimuli-responsive properties as carriers for efficient loading. The gel undergoes volume/structural changes in response to external stimuli (such as pH, temperature, ion strength, etc.), thereby controlling the release kinetics. By optimizing gel composition and preparation methods, high sensitivity to specific pathological environments can be achieved, enabling active targeting delivery and responsive release to enhance accumulation at lesion sites while minimizing off-target organ toxicity. Comprehensive biocompatibility and efficacy evaluations confirm outstanding performance of this system, offering innovative solutions for targeted therapy and smart controlled release.